Tenofovir gel--the new HIV prevention 'banker'?
نویسنده
چکیده
The tenofovir trial is being conducted among 1 000 HIV-negative women attending the Ethekwini Clinical Research Site in Durban and the rural Mafakathini clinic at Vulindlela, 90 km Unlike the controversial two failed microbicides (Ushercell cellulose sulphate-based vaginal gel and nonoxynol-9), where trial participants seroconverted, the tenofovir gel does not act in the vaginal lumen to kill the virus. Lead investigators of the Durban tenofovir microbicide gel trials, Professors Salim and Quarraisha Abdool Karim with UNAIDS chief scientific advisor Catherine Hankins (centre). Picture: Chris Bateman
منابع مشابه
Re.: Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide reverse transcriptase inhibitor, for the prevention of HIV acquisition in women. A double-blind, randomized controlled trial was conducted comparing tenofovir gel (n = 445 women) with placebo gel (n = 444 women) in sexua...
متن کاملA drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.
INTRODUCTION More than a million people acquire HIV infection annually. Pre-exposure prophylaxis (PrEP) using antiretrovirals is currently being investigated for HIV prevention. Oral and topical formulations of tenofovir have undergone preclinical and clinical testing to assess acceptability, safety and effectiveness in preventing HIV infection. AREAS COVERED The tenofovir drug development pa...
متن کاملUnderstanding microbicide acceptability
In July 2010, the CAPRISA 004 trial demonstrated that a vaginal microbicide gel containing the antiretroviral drug tenofovir, reduced the risk of HIV infection for women by 39%. A confirmatory trial, FACTS 001, is ongoing in South Africa. If tenofovir microbicide gel is proven to reduce the risk of HIV acquisition, it could be available as an additional HIV prevention option for women in the fo...
متن کاملFrom trials to the public health
Two point two million adults were newly HIV-infected in 2011, underscoring the urgent need for new, effective ways to prevent incident infections1. Recently, the field of HIV prevention has gathered positive results from different strategies, among different populations, and with varying effect sizes, including the treatment of HIV-positive women and men in discordant couples2-4, male circumcis...
متن کاملInterim statement on HIV pre-exposure prophylaxis (PrEP)
In recent years, a number of randomised clinical trials have been completed overseas wherein antiretrovirals in various formats were evaluated for the prevention of HIV infection.1,2 Subjects ranged from men who have sex with men (MSM), heterosexual men and women, to people who inject drugs. Major antiretrovirals evaluated included coformulated tenofovir disoproxil fumarate / emtricitabine (TDF...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
دوره 97 7 شماره
صفحات -
تاریخ انتشار 2007